منابع مشابه
Lighting up mRNA localization in Drosophila oogenesis.
The asymmetric localization of four maternal mRNAs - gurken, bicoid, oskar and nanos - in the Drosophila oocyte is essential for the development of the embryonic body axes. Fluorescent imaging methods are now being used to visualize these mRNAs in living tissue, allowing dynamic analysis of their behaviors throughout the process of localization. This review summarizes recent findings from such ...
متن کاملPre-mRNA Secondary Structures Influence Exon Recognition
The secondary structure of a pre-mRNA influences a number of processing steps including alternative splicing. Since most splicing regulatory proteins bind to single-stranded RNA, the sequestration of RNA into double strands could prevent their binding. Here, we analyzed the secondary structure context of experimentally determined splicing enhancer and silencer motifs in their natural pre-mRNA c...
متن کاملLighting up FGFR signaling.
In this issue of Chemistry & Biology, Kim and colleagues describe their work on optogenetic control of fibroblast growth factor receptor (FGFR) signaling. By engineering a chimeric receptor, the authors demonstrate that FGFR intracellular signaling can be controlled in space and time by blue light.
متن کاملGFP: Lighting up life.
I want to thank the Royal Swedish Academy of Sciences and the Nobel Foundation for this amazing and surprising honor. At first I wondered why I, a biologist and a person with less than enviable college grades in chemistry, had been selected. Then I realized that this prize had actually been given to the GFP molecule, and I am one of its assistants. Thank you for letting me be part of the celebr...
متن کاملLighting Up the Mechanome
biological machinery—the " mechanome " —will open the way to new strategies for fighting disease. Genomics and general " omics " approaches, such as proteomics, inter-actomics, and glycomics, among others, are powerful system-level tools in biology. All of these fields are supported by advances in instrumentation and computation, such as DNA sequencers and mass spectrometers, which were critica...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2014
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2014.08.021